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Lopinavir and Ritonavir tablet is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
The following points should be considered when initiating therapy with lopinavir and ritonavir tablet: The use of other active agents with lopinavir and ritonavir tablet is associated with a greater likelihood of treatment response (see Pharmacology: Microbiology under Actions and Pharmacology: Pharmacodynamics: Clinical Studies under Actions).
Genotypic or phenotypic testing and/or treatment history should guide the use of lopinavir and ritonavir tablet (see Pharmacology: Microbiology under Actions). The number of baseline primary protease inhibitor mutations affects the virologic response to lopinavir and ritonavir tablet (see Pharmacology: Microbiology under Actions).
Once daily administration of lopinavir and ritonavir tablet is not recommended for therapy-experienced adult patients or any pediatric patients.
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