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Some caution is required when prescribing terazosin with other antihypertensive agents as significant hypotension has been observed. Dose re-titration may be required when diuretics or antihypertensives are added to the medication regimen.
Combination of terazosin with other alpha-receptor blockers is not recommended.
Furthermore, the antihypertensive effect may be increased when terazosin is administered concomitantly with vasodilators and nitrates.
Concomitant administration of PDE-5-inhibitors (such as sildenafil, tadalafil and vardenafil) and terazosin may lead to symptomatic hypotension in some patients (see Precautions).
Sympathomimetics may reduce the antihypertensive effect of terazosin; terazosin may reduce blood pressure and vascular reactions to dopamine, ephedrine, epinephrine, metaraminol, methoxamine and phenylephrine.
Terazosin may influence plasma renin activity and urinary excretion of vanillylmandelic acid. This should be considered when interpreting laboratory data.
Terazosin reduces the hypertensive effect of intravenously administered clonidine.
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