RiteMED Simvastatin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Simvastatin

Indications/Uses

CHD. Reduction of total LDL-cholesterol, apolipoprotein B & triglycerides in the treatment of hyperlipidemia including hypercholesterolemia, adjunct therapy for homozygous familial hypercholesterolemia & ischemic heart disease.

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Dosage/Direction for Use

CHD Initially, 20 mg once daily at bedtime, may increase at 4-wk intervals to max 80 mg/day. Hyperlipidemia 10-20 mg once daily at bedtime. Homozygous familial hypercholesterolemia 40 mg once daily at bedtime or 80 mg/day in 3 divided doses (20, 20 & 40 mg in the morning, afternoon & evening). Renal insufficiency 5-10 mg.

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Administration

May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.

Contraindications

Acute liver disease or unexplained elevations in serum transaminases. Porphyria, pregnancy, women of childbearing potential & lactation.

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Special Precautions

Monitor liver enzyme levels periodically. Alcoholics & patients w/ liver disease.

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Adverse Reactions

Constipation, dyspepsia, flatulence, pain, diarrhea, asthenia, nausea/vomiting & headache. Rhabdomyolysis w/ acute renal failure secondary to myoglobinuria occurred rarely & requires discontinuance.

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Drug Interactions

Coumarin derivatives, digoxin, protease inhibitors, itraconazole, ketoconazole, fibrates, niacin, cyclosporine, erythromycin, verapamil, diltiazem & grapefruit juice.

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Storage

View RiteMED Simvastatin storage conditions for details to ensure optimal shelf-life.

Description

View RiteMED Simvastatin description for details of the chemical structure and excipients (inactive components).

Action

View RiteMED Simvastatin mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Dyslipidaemic Agents

ATC Classification

C10AA01 - simvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.

Regulatory Classification

Presentation/Packing

Form

RiteMED Simvastatin FC tab 20 mg

Packing/Price

30's (P480/box, P16/film-coated tab)

Form

RiteMED Simvastatin FC tab 40 mg

Packing/Price

30's (P720/box, P24/film-coated tab)

RiteMED Simvastatin

simvastatin

Manufacturer:

RiteMED

Distributor:

United Lab