If a previously effective dose fails to provide the usual relief or the usual duration of effect is reduced, consult a physician for medical advice as this may be a sign of worsening of asthma that would require reassessment of therapy.
Paradoxical bronchospasm, a pontentially life-threatening event, may occur with the administration of oral Salbutamol. If it occurs, discontinue use of the product immediately.
Use with caution in acute severe asthma where concomitant therapy with steroids, xanthine derivatives, or diuretics, and by hypoxia may result in hypokalemia; plasma potassium concentrations should be monitored in severe asthma.
Treatment with Salbutamol and other beta2-agonists may decrease plasma potassium concentration possibly through intracellular shunting resulting in cardiovascular adverse effects.
Use with caution in patients with the following conditions: Cardiovascular disorders including coronary sufficiency, cardiac arrhythmias or hypertension; Convulsive disorders; Hyperthyroidism; Diabetes mellitus; In patients who are unusually responsive to synpathomimetic amines.
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