RiteMED Pantoprazole Dosage/Direction for Use

Alternative to oral therapy: IV Pantoprazole is not indicated for mild gastrointestinal complaints such as nervous dyspepsia.
Pantoprazole should be administered IV over 2 to 15 minutes.
Pantoprazole should not be administered concomitantly with any other medications through the same IV line.
The IV line should always be flushed with either 0.9% sodium chloride solution or 5% dextrose solution before and after administration.
As soon as oral treatment is possible, IV administration of pantoprazole should be discontinued and the treatment should be continued orally.
Gastric and duodenal ulcer, moderate and severe reflux esophagitis: Recommended Dose: 40 mg per day.
For the management of reflux esophagitis, pantoprazole can be administered either by slow IV injection over 2 to 5 minutes, or by IV infusion over 15 minutes.
Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: Recommended Initial Dose: 80 mg IV injection per day.
The dose and duration of treatment should be adjusted according to patient's response.
Daily doses above 80 mg should be administered in two divided doses.
Doses above 160 mg may be used temporarily but should not be administered longer than required for adequate acid control.
In case a rapid acid control is needed, a starting dose of 160 mg is sufficient to manage a decrease of acid output into the target range (<10 mEq/h) within one hour in the majority of patients.
Treatment of bleeding peptic ulcer and prevention of re-bleeding: Recommended Dose: 80 mg IV bolus followed by infusion of 8 mg/h for 3 days.
Prophylaxis of acute bleeding stress ulcer: Recommended Dose: 40 to 80 mg once or twice a day.
The solution may be given as a bolus for at least 2 minutes, or as an infusion for 15 minutes.
Dosage in Elderly: The daily dose should not exceed 40 mg.
Dosage in Patients with Hepatic Impairment: The daily dose should not exceed 20 mg in patients with severe hepatic impairment.
Dosage in Patients with Renal Impairment: The daily dose should not exceed 40 mg.