Naproxen should be used with caution in renal impairment, and use is not recommended in patients whose creatinine clearance is less than 20 mL/min; Contraindicated in patients with active peptic ulceration; Should be used with caution in patients with hypertension, infections, asthma or allergic disorders or impaired renal or hepatic function; Should be used with caution in the elderly and may need to be given in reduced doses.