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Pregnancy: Pregnancy Category C. Although there are no adequate and controlled studies to date in humans, metoprolol has been shown to increase post-implantation loss and to decrease neonatal survival in rats when given at metoprolol tartrate dosages up to 55.5 times the maximum recommended human dosage of 450 mg daily. Metoprolol should be used in pregnancy only if clearly needed.
Lactation: Since metoprolol is distributed into milk, the drug should be used with caution in breastfeeding mothers.
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