Risgen Drug Interactions

Centrally-Acting Drugs and Alcohol: Risperidone should be used with caution when taken in combination with other centrally-acting drugs and alcohol given the primary CNS effects of risperidone.
Drugs with Hypotensive Effects: Because of its potential for inducing hypotension, risperidone may enhance the hypotensive effects of other therapeutic agents with this potential.
Levodopa and Dopamine Agonists: Risperidone may antagonize the effects of levodopa and dopamine agonist.
Cimetidine and Ranitidine: Cimetidine and ranitidine increased the bioavailability of risperidone by 64% and 26%. Cimetidine did not affect the AUC of risperidone, whereas ranitidine increased the AUC of risperidone and 9-hydroxyrisperidone combined by 20%.
Clozapine: Chronic administration of clozapine with risperidone may decrease the clearance of risperidone.
CYP Enzyme Inducers: Co-administration of risperidone with enzyme inducers (e.g. carbamazepine, rifampin, phenytoin, and carbamazepine) may cause decrease in the combined plasma concentration of risperidone and 9-hydroxyrisperidone, which could lead to decreased efficacy of risperidone treatment.