Sign Out
Contraindicated combinations: Iodinated contrast materials: Depending on the renal function, metformin must be discontinued 48 hours before the test or from the time of the test and may not be reinstituted until 48 hours afterwards (see Contraindications and Precautions).
Concomitant use not recommended: Alcohol: Increased risk of lactic acidosis in acute alcohol intoxication particularly in case of: fasting or malnutrition; hepatic insufficiency.
Avoid consumption of alcohol and alcohol-containing medications.
Combinations requiring precautions for use: Medicinal products with intrinsic hyperglycemic activity (e.g. glucocorticoids (systemic and local routes) and sympathomimetics): More frequent blood glucose monitoring may be required especially at the beginning of treatment. If necessary, adjust the metformin dosage during therapy with the respective medicinal product and upon its discontinuation.
Diuretics, especially loop diuretics: They may increase the risk of lactic acidosis due to their potential to decrease renal function.
Continue with Google