Renalog Max Mechanism of Action

Pharmacological classification: Renal Nutrition Therapy (Nutrition Therapy in Chronic Kidney Disease).
Pharmacology: Pharmacodynamics: Alpha ketoanalogues + Essential Amino Acids allows the intake of essential amino acids while the intake of the amino nitrogen is minimized.
The alpha keto-analogues are transaminated after ingesting by extracting nitrogen from non-essential amino acids, therefore reducing the formation of urea by reusing the amino group.
The accumulation of uremic toxins are reduced. Hyperfiltration of remaining nephrons is not elicited by keto and/or hydroxyl-acids. Supplements containing ketoacids have a positive effect on renal hyperphosphatemia, and secondary hyperparathyroidism can help to improve renal osteodystrophy.
The usage of Alpha Ketoanalogues + Essential Amino Acids in conjunction with a very low protein diet allows for a reduction in nitrogen intake while avoiding the negative effects of a lack of dietary protein and malnutrition.
Pharmacokinetics: The plasma kinetics of essential amino acids and their integration in the metabolic pathways are well established. It should be noted that the plasma disturbances in uremic patients do not appear to be dependent on digested amino acid intake, and that the post-absorptive kinetics appears to be distributed very early in the disease's development in normal individuals. There is an increase in the plasma level of alpha ketoanalogues 10 minutes after oral ingestion. Peak levels are reached within 20-60 minutes, and normal levels are reached again after 90 minutes. Gastrointestinal absorption is hence very rapid. The simultaneous increases in the levels of Alpha Ketoanalogues + Essential Amino Acids and the corresponding amino acids indicate that the Alpha Ketoanalogues + Essential Amino Acids are very rapidly transaminated. Exogenously supplied Essential Amino Acids are expected to be very rapidly integrated into the metabolic cycle due to the physiological utilization pathways of Essential Amino Acids in the body. Ketoacids follow the same catabolic pathways as classical amino acids. No specific study on Alpha Ketoanalogues + Essential Amino Acids excretion has been performed to date.