Refluxid Duo Drug Interactions

Pantoprazole: Pantoprazole is less likely than Omeprazole to interact with other drugs. The absorption of certain drugs may be affected by stomach acidity, and, as a result, pantoprazole and other PPI's that reduce stomach acid also reduce the absorption and concentration in blood of Ketoconazole and increase the absorption and concentration in blood of Digoxin. This may lead to reduced effectiveness of ketoconazole or increase digoxin toxicity, respectively.
Domperidone: The concomitant administration of anticholinergic drugs may compromise the beneficial effects of domperidone. Since domperidone enhances gastric and small intestinal motility, it may accelerate absorption of drugs from the small bowel while slowing absorption of drugs taken up from the stomach. Care should be exercised when Domperidone is administered in combination with MAO inhibitors. The concomitant administration of domperidone with antacids or H2 receptor blockers does not decrease the absorption of domperidone.