Pterin Dosage/Direction for Use

Tablet: Acute lymphoblastic leukemia: 15 to 30 mg/m² once or twice weekly.
Choriocarcinoma: 15 to 30 mg daily for 5 days at intervals of 1 to 2 weeks for 3 to 5 courses.
Burkitt's lymphoma: 10 to 25 mg daily by mouth for 4 to 8 days repeated after an interval of 7 to 10 days.
Mycosis fungoides: 2.5-10 mg daily to induce remission.
Severe psoriasis: 10-25 mg orally, once weekly, is recommended, however, intravenous or intramuscular methotrexate can also be administered. Divided oral dose schedule is 2.5 mg at 12-hour intervals for three doses. Dosage should be adjusted according to the patient's response and hematological toxicity.
Rheumatoid Arthritis: 7.5 mg by mouth once weekly.
Injection: Meningogenic leukemia for children: 12 mg/m² or 15 mg whichever is less (about 0.4-0.5 mg/kg) intrathecal once or twice weekly.
Acute lymphoblastic leukemia: 15 to 30 mg/m² once or twice weekly intramuscularly. Alternately, 2.5 mg/kg IV every 14 days.
Choriocarcinoma: 15 to 30 mg daily intramuscularly for 5 days at intervals of 1 to 2 weeks for 3 to 5 courses. Alternately, 0.25 to 1 mg/kg up to max of 60 mg IM every 48 hours for 4 doses followed by folinic acid rescue and repeated at intervals of 7 days.
Mycosis fungoides: 50 mg weekly as a single dose IM.
Osteogenic sarcoma: 12-15 g/m² IV infusion followed by folinic acid.
Severe psoriasis: 10-25 mg orally, once weekly, is recommended, however, intravenously or intramuscularly is administered. Dosage should be adjusted according to the patient's response and hematological toxicity.
Administration: Small amount administration (IV or IM).
Large amount administration (Rapid IV (bolus injection) or infusion).
Intrathecal or intraarterial administration.
It is administered through tube for infusion over 2-3 minutes. In administration of over 100 mg, IV infusion should be done within 24 hours (In initial administration, bolus administration). Dosage over 70 mg/m² (2.3 mg/kg) should be administered concomitantly with leucovorin rescue therapy, or serum methotrexate level of 24-48 hours after administration should be observed.
Methotrexate should be used alone or concomitantly with radiotherapy, surgical therapy.
Determination of dosage should be considered.