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Methotrexate has been used to produce regression in a wide range of neoplastic conditions including: Acute leukemias.
Trophoblastic neoplasms (choriocarcinoma, hydatidiform mole).
Non-Hodgkin's lymphoma such as Burkitt's lymphoma, mycosis fungoides.
Osteogenic sarcomas.
Solid tumors particularly breast, lungs, head and neck, bladder, cervical, ovarian and testicular carcinoma.
Methotrexate is also used in the treatment of rheumatoid arthritis and severe, uncontrolled psoriasis, which is not responsive to other therapy.
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