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Significant lethality was observed in mice and rats after oral administration of 1000mg/kg and 2000mg/kg, respectively, about 44 and 170 times the maximum recommended human dose on an mg/m2 basis. Limited data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted.
Neither Losartan nor its active metabolite can be removed by hemodialysis.
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