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Probenecid: Probenecid interferes with renal secretion of Ciprofloxacin. Co-administration of Probenecid and Ciprofloxacin increases Ciprofloxacin serum concentrations.
Effects of ciprofloxacin on other medicinal products: Tizanidine: Tizanidine must not be administered together with Ciprofloxacin. In a clinical study with healthy subjects, there was an increase in serum tizanidine concentration (Cmax increase: 7-fold, range: 4 to 21-fold; AUC increase: 10-fold, range: 6 to 24-fold) when given concomitantly with Ciprofloxacin. Increased serum Tizanidine concentration is associated with a potentiated hypotensive and sedative effect.
Methotrexate: Renal tubular transport of Methotrexate may be inhibited by concomitant administration of Ciprofloxacin, potentially leading to increased plasma levels of Methotrexate and increased risk of Methotrexate-associated toxic reactions. The concomitant use is not recommended.
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