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Pharmacotherapeutic group: Selective beta-2-adrenoreceptor agonists. ATC Code: R03CC02.
Pharmacology: Pharmacodynamics: As a beta-adrenergic stimulant for relief of bronchospasm such as occurs with asthma, bronchitis, emphysema. It has a highly selective action on the receptors in bronchial muscle and in therapeutic dosage, little or no action on the cardiac receptors.
Pharmacokinetics: Salbutamol is readily absorbed from the gastro-intestinal tract and is subject to first pass metabolism in the liver. Peak plasma concentrations occur within one to four hours after oral administration. After multiple oral doses of salbutamol 2 mg four times a day, steady-state plasma concentrations are obtained after 3 days. About half is excreted in the urine as an inactive sulfate conjugate following oral administration. The bioavailability of orally administered salbutamol is about 50%.
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