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Diarrhoea may occur in overdose with UDCA. In this case, the dose must be reduced, and if diarrhoea persist, the treatment must be discontinued.
In general, other symptoms of overdose are unlikely because the absorption of ursodeoxycholic acid decreases with increasing dose and therefore more is excreted with the faeces.
No specific counter-measures are necessary. If diarrhoetic stools occur, these should be treated symptomatically with fluids and electrolytes.
Other information for special patient groups: Long-term treatment with high doses of UDCA (28-30 mg/kg/day) in patients with primary sclerosing cholangitis has been associated with an increased incidence of serious adverse reactions.
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