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Denosumab (Prolia) is contraindicated in: Hypocalcemia: Pre-existing hypocalcemia must be corrected prior to initiating therapy with denosumab (Prolia) [see Hypocalcemia and Mineral Metabolism under Precautions].
Pregnancy: Denosumab (Prolia) may cause fetal harm when administered to a pregnant woman. In women of reproductive potential, pregnancy testing should be performed prior to initiating treatment with denosumab (Prolia) [see Use in Pregnancy & Lactation].
Hypersensitivity: Denosumab (Prolia) is contraindicated in patients with a history of systemic hypersensitivity to any component of the product. Reactions have included anaphylaxis, facial swelling, and urticaria [see Hypersensitivity under Precautions and Postmarketing Experience under Adverse Reactions].
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