Preva M Adverse Reactions

Mecobalamin: Allergic hypersensitivity reactions have occurred rarely after parenteral doses of the vitamin B12 compounds cyanocobalamin and Hydroxocobalamin. Antibodies to Hydroxocobalamin-transcobalamin II complex have developed during Hydroxocobalamin therapy. Arrhythmias secondary to hypokalemia have occurred at the beginning of parenteral treatment with Hydroxocobalamin. Intranasal cyanocobalamin may cause rhinitis, nausea, and headache.
Pregabalin: The most common adverse effects reported during therapy with pregabalin are dizziness and somnolence. Other common adverse effects include blurred vision, diplopia, increased appetite and weight gain, dry mouth, constipation, vomiting, flatulence, euphoria, confusion, reduced libido, erectile dysfunction, irritability, vertigo, ataxia, tremor, dysarthria, paraesthesia, fatigue, and edema. Disturbances of attention, memory, coordination, and gait also occur frequently. Syncope and congestive heart failure have been reported less frequently. Reversible renal failure, elevation of creatine kinase concentration, and rhabdomyolysis have been reported rarely. Hypersensitivity reactions have occurred shortly after starting pregabalin therapy; symptoms include rash, blisters, urticaria, dyspnea, and wheezing. Stevens-Johnson syndrome has also been reported. An increased incidence of hemangiosarcoma was observed in mice that had been given high doses of pregabalin.