No clinically significant interactions were observed with carbamazepine, caffeine, diazepam, diclofenac, digoxin, ethanol, glibenclamide, metoprolol, phenytoin, warfarin and concomitantly administered antacids. As with other antacid secretion inhibitors, changes in absorption may be observed with drugs whose absorption is pH dependent eg, ketoconazole are taken concomitantly.