Pioglitazone is well tolerated. The most common adverse reaction with Pioglitazone includes gastrointestinal disturbances, weight gain, edema, anemia, headache, visual disturbances, dizziness, arthralgia, hypoesthesia, haematuria, upper respiratory tract infection, and sinusitis.
Less commonly: Hypoglycemia, fatigue, insomnia, vertigo, sweating, altered blood lipids, and proteinuria.