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Pharmacology: Polymyxin is bactericidal and most effective against Pseudomonas aeruginosa. Development of resistant strains is rare. The following gram negative organisms are highly susceptible to polymyxin: Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Koch-Weeks bacillus.
Neomycin sulfate is a broad spectrum antibiotic. Some organisms which are sensitive of this antibiotic are: Staphylococcus aureus, Corynebacterium diptheriae, E. coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes and Haemophilus influenzae.
Dexamethasone is the most potent of a series of 16-methyl substituted hydrocortisone analogs and readily penetrates the cornea. It causes inhibition of the inflammatory response to inciting agents of a mechanical, chemical or immunological nature. No generally accepted explanation of this steroid property has been advanced.
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