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In case of overdoses, intoxication or iron accumulation are unlikely due to the low toxicity of iron (III) hydroxide polymaltose complex [in mice or rats, the 50% lethal dose (LD50) > 2000 mg Fe/Kg body weight] and the expected saturation of the iron intake is unlikely. There are no known cases of accidental fatal poisoning.
There are reports that an excessive dose of folic acid may cause changes in the central nervous system (namely, mood disorders, changes in sleep patterns, irritability and hyperactivity), nausea, abdominal distension and flatulence.
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