Combined administration of acetylcysteine with antitussives may cause dangerous secretory congestion due to the reduced cough reflex, so that an especially careful diagnosis is required for this combination treatment.
Reports to date on an inactivation of antibiotics due to acetylcysteine exclusively refer to in vitro experiments in which the relevant substances were mixed directly. Nevertheless for safety reasons, oral antibiotics should be administered separately and at an interval of at least 2 hours. This does not apply to cefixime and loracarbef.
Acetylcysteine may potentiate the vasodilatory effect of nitroglycerin. Caution is advised.
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