Pipzo Hospi Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Piperacillin Na 4 g, tazobactam Na 500 mg

Indications/Uses

Moderate to severe infections eg, appendicitis (complicated by rupture or abscess), peritonitis, uncomplicated skin & skin structure infections including cellulitis, cutaneous abscesses & ischemic/diabetic foot infections, post-partum endometritis or pelvic inflammatory disease, moderate to severe community-acquired pneumonia, moderate to severe nosocomial pneumonia.

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Dosage/Direction for Use

IV infusion Infuse for 30 min. Adult 3.375 g every 6 hr for 7-10 days. Nosocomial pneumonia 4.6 g every 6 hr for 7-14 days w/ an aminoglycoside. Renal impairment CrCl >40 mL/min 4.5 g every 6 hr, 20-40 mL/min (patient not receiving hemodialysis) 3.375 g every 6 hr, <20 mL/min (patient not receiving hemodialysis) 2.25 g every 6 hr. Hemodialysis 2.25 g every 8 hr. Administer 0.75 g following each hemodialysis session on hemodialysis days. CAPD 2.25 g every 8 hr. All indications (except nosocomial pneumonia) Renal impairment CrCl >40 mL/min 3.375 g every 6 hr, 20-40 mL/min (patient not receiving hemodialysis) 2.25 g every 6 hr, <20 mL/min (patient not receiving hemodialysis) 2.25 g every 8 hr. Hemodialysis 2.25 g every 12 hr. Administer 0.75 g following each hemodialysis session on hemodialysis days. CAPD 2.25 g every 12 hr. Appendicitis &/or peritonitis Childn ≥9 mth weighing up to 40 kg 100 mg/12.5 mg/kg every 8 hr, 2-9 mth 80 mg/10 mg/kg every 8 hr. Patient weighing >40 kg Adult dose.

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Overdosage

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Contraindications

History of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.

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Special Precautions

Anaphylactic/anaphylactoid reactions including shock. SJS, TEN. Discontinue treatment if patients develop a skin rash & lesions progress; bleeding manifestations occur; C. difficile associated diarrhea is suspected or confirmed. Periodic assessment of hematopoietic function especially w/ prolonged therapy (≥21 days); electrolyte determinations in patients w/ low K reserves. Neuromuscular excitability or convulsions in higher doses. Nephrotoxicity in critically ill patients. Concomitant use w/ vancomycin. Development of drug-resistant bacteria. False +ve reaction for glucose in the urine using a Cu-reduction method (CLINITEST). Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea, constipation, nausea, vomiting, dyspepsia, abdominal pain; fever, inj site reactions, rigors; anaphylaxis, candidiasis, pseudomembranous colitis; hypoglycemia; myalgia, arthralgia, headache; insomnia; rash including maculopapular, bullous & urticaria, pruritus, purpura; phlebitis, thrombophlebitis, hypotension, flushing; epistaxis. Nosocomial pneumonia: Thrombocytopenia, anemia, thrombocythemia, eosinophilia; stomatitis; oral candidiasis, candidiasis; increased BUN, blood creatinine, ALT, AST, alkaline aminotransferase, abnormal LFT; hypokalemia, renal failure. Nephrotoxicity.

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Drug Interactions

May inactivate aminoglycosides by converting them to microbiologically inert amides. Prolonged t^₁_/2 w/ probenecid. Increased incidence of acute kidney injury w/ vancomycin. Prolongation of the neuromuscular blockade of vecuronium. May reduce the clearance of MTX. Anticoagulants.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Pipzo Hospi detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Penicillins

ATC Classification

J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Pipzo Hospi powd for infusion

Packing/Price

1's

Pipzo Hospi

piperacillin + tazobactam

Manufacturer:

Inject Care Parenterals

Distributor:

Alkem Lab