Perispa Mechanism of Action

Pharmacology: Skeletal muscle relaxation, relaxation of hypertonic skeletal muscles, improves intramuscular blood flow, suppression of spinal reflex potentials, reduction of muscle spindle sensitivity via motor neurons, vasodilatation and augmentation of blood flow, analgesic action and inhibition of the pain reflex in the spinal cord.
Efficacy: Data based on the assessment of 8660 clinical reports of Eperisone hydrochloride (Perispa) usage - Oct. 1982 to Sept, 1986.
Symptom Rate of Improvement (%): Rigidity 70.2, Stiffness 70.4, Dizziness 77.4, Headache 78.9, Tinnitus 65.9, Cervical pain 71.6, Stiff shoulder 82.1, Lumbago 74.8, Difficulty in going up & downstairs 55.2, Difficulty in walking 56.5.
Pharmacokinetics: The pharmacokinetic properties of Eperisone hydrochloride (Perispa) after a single dose of 150 mg/day orally for 14 consequent days to 8 healthy adult male volunteers: T_max: 1.6 to 1.9 hr.
C_max: 7.5 to 7.9 ng/ml.
Elimination half life: 1.6 to 1.8 hr.
Area under the plasma concentration time curve (AUC): 19.7 to 21.1 ng.hr/ml.
The plasma concentration profiles of Eperisone hydrochloride (Perispa) determined at day 8 and day 14 did not significantly vary from those of the first day.