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This combination is not suitable for the treatment of insulin-dependent (type I) diabetes mellitus (e.g. for the treatment of diabetics with a history of ketoacidosis), or of oral diabetic precoma or coma.
It must not be used in patients with sensitivity to metformin HCl, glimepiride, sulfonylureas, other sulfonamides, or any of the excipients (risk of hypersensitivity reactions).
Impaired renal function; Acute complications (severe infections, major operations & trauma), before x-ray examinations with iodinated contrast materials; Liver damage; Alcoholism; Deficiencies of vitamin B12, folic acid and iron; Ketosis-prone diabetes; Severe cardiovascular or respiratory disease; General ill health (malnutrition, dehydration, etc); Diabetes with significant late complications (nephropathy, retinopathy).
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