Sign Out
Tablet/Suppository: There is lack of experience in overdosage. The physician should be contacted if an overdosage is suspected.
Granules: Acute experience in animals: Single oral doses of mesalazine up to 5 g/kg in pigs or a single intravenous dose of mesalazine at 920 mg/kg in rats were not lethal.
Human experience: There are limited clinical experience with overdose of Mesalazine (Pentasa) which do not indicate renal or hepatic toxicity. Since Mesalazine (Pentasa) is an amino salicylate, symptoms of salicylate toxicity, such as acid-base balance disorder, hyperventilation, pulmonary edema, vomiting, dehydration and hypoglycaemia, may occur. Symptoms of salicylate over dosage is well described in the literature.
There have been reports of patients taking daily doses of 8 grams for a month without any adverse events.
There is no specific antidote and the management of overdose is supportive and symptomatic. The treatment at the hospital includes close monitoring of renal function.
Continue with Google