Peldacyn Dosage/Direction for Use

Capsule: Adults, adolescents over 14 years of age and older: 600-1800 mg/day divided into 3-4 equal doses.
For doses that cannot be reached by clindamycin, 450 mg or clindamycin 600 mg tablets other pharmaceutical forms with lower doses are available.
Children and adolescents: Depending on location and severity of infection children and adolescents (4 weeks to 14 years) take 8 to 25 mg clindamycin/kg bodyweight/day.
For this age group other pharmaceutical forms with lower doses are available.
Patients with hepatic impairment: Prolongation of clindamycin half-life has been observed in patients with mild to moderate hepatic impairment. However, pharmacokinetic studies have shown that accumulation occurs only rarely when clindamycin is administered every 8 hours.
In patients with severe liver insufficiency the blood level of clindamycin should be monitored carefully. Accordingly, dose reduction or prolongation of the dose interval can be necessary.
Patients with renal impairment: Prolongation of clindamycin half-life has been observed in patients with renal impairment. However, in patients with mild to moderate renal impairment dose reduction is not necessary.
In patients with severe renal insufficiency or anuria, the blood level of clindamycin should be monitored carefully. Accordingly, dose reduction or prolongation of the dosage interval to 8 or even 12 hours can be necessary.
Dosage in haemodialysis patients: Clindamycin cannot be removed by haemodialysis. No increase in dose is therefore required before or after dialysis.
Method and duration of treatment: To avoid oesophageal irritation the tablets should always be taken with full glass of water.
Treatment should last for at least 10 days in infections due to β-haemolytic streptococci.
Solution for Injection: Adult: Serious Infection: 600-1200 mg/day divided in 2-4 equal doses.
More Severe Infection: 1200-2700 mg/day divided in 2-4 equal doses.
Children (≥1 month): Serious Infection: 15-25 mg/kg/day in 3-4 equal doses.
More Severe Infection: 25-40 mg/kg/day in 3-4 equal doses.
Neonates (<1 month): 15-20 mg/kg/day in 3-4 equal doses. Lower dosage may be adequate for small premature infants. If it improves the condition as IV administration, it may be changed to oral dosing (capsule, syrup) by physician's opinion. In cases of β-hemolytic Streptococcal infections, treatment should continue for at least 10 days.
Administration: Clindamycin should not be injected intravenously undiluted as a bolus and should not be infused over at least 10-60 min as indicated as follows. Drug may be administered in the form of a single rapid infusion of the 1st dose followed by continuous IV infusion as follows, for maintaining serum clindamycin level. (See Table 3.)

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