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No formal drug interaction studies have been performed.
Antineoplastic Agents: Concomitant use of Pegfilgrastim with fluorouracil or other antimetabolites has not been evaluated in patients.
Lithium: Potential pharmacologic interaction (potentiation of neutrophils release); more frequent monitoring of neutrophils counts is recommended.
As a response to the growth factor therapy, increased hematopoietic activity of the marrow is manifested as transient positive bone imaging changes which should be considered while interpreting bone imaging results.
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