Operol Drug Interactions

The induction dose requirements of Propofol injectable emulsion may be reduced in patients with intramuscular or intravenous premedication, particularly with narcotics (e.g., morphine, meperidine and fentanyl, etc) and combinations of opioids and sedatives (e.g., benzodiazepines, barbiturates, chloral hydrate, droperidol, etc.).
These agents may increase the anesthetic or sedative effects of Propofol injectable emulsion and may also result in more pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output.
During maintenance of anesthesia or sedation, the rate of Propofol injectable emulsion administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental analgesic agents (e.g., nitrous oxide or opioids). The concurrent administration of potent inhalational agents (e.g., isoflurane, enflurane, and halothane) during maintenance with Propofol injectable emulsion has not been extensively evatuated. These inhalational agents can also be expected to increase the anesthetic or sedative and cardiorespiratory effect of Propofol injectable emulsion.
Propofol injectable emulsion does not use a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents, succinylcholine and nondepolarizing muscle relaxants). No significant adverse interactions with commonly used premedication or drugs used during anesthesia or sedation (including a range of muscle relaxants, observed in adults. In pediatric patients, administration of fentanyl concomitantly with prenatal injectable emulsion may result in serious bradycardia.