Omnivox Drug Interactions

Effect of other medicinal products on Levofloxacin tablets: Iron salts, magnesium- or aluminum-containing antacids: Levofloxacin absorption is significantly reduced when iron salts, or magnesium- or aluminum-containing antacids are administered concomitantly with Levofloxacin tablets. It is recommended that preparations containing iron salts, or magnesium-or aluminum-containing antacids should not be taken 2 hours before or after Levofloxacin tablet administration. No interaction was found with calcium carbonate.
Sucralfate: The bioavailability of levofloxacin tablets is significantly reduced when administered together with sucralfate. If the patient is to receive both sucralfate and Levofloxacin tablets, it is best to administer sucralfate 2 hours after the Levofloxacin tablet administration.
Theophylline, fenbufen or similar non-steroidal anti-inflammatory drugs: A pronounced lowering of the cerebral seizure threshold may occur when quinolones are given concurrently with theophylline, non-steroidal anti-inflammatory drugs, or other agents which lower the seizure threshold. Levofloxacin concentrations were about 13% higher in the presence of fenbufen than when administered alone.
Probenecid and cimetidine: Probenecid and cimetidine has statistically significant effect on the elimination of levofloxacin. The renal clearance of levofloxacin is reduced by cimetidine (24%) and probenecid (34%). Caution should be exercised when levofloxacin is coadministered with drugs that affect the tubular renal secretion such as probenecid and cimetidine, especially in renally impaired patients.
Other relevant information: Pharmacokinetics of levofloxacin is not affected when coadministered with the following drugs: calcium carbonate, digoxin, glibenclamide, ranitidine.
Effect of Levofloxacin tablets on other medicinal products: Ciclosporin: The half-life of ciclosporin was increased by 33% when coadministered with levofloxacin.
Vitamin K antagonists: Increased coagulation tests (PT/INR) and/or bleeding have been reported in patients treated with levofloxacin in combination with a vitamin K antagonist (e.g. warfarin). Coagulation tests should be monitored in patients treated with vitamin K antagonists.
Drugs known to prolong QT interval: Levofloxacin should be used with caution in patients receiving drugs known to prolong the QT interval (e.g. Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides).
Other forms of interactions: Meals: There is no clinically relevant interaction with food.