Omniscan Dosage/Direction for Use

No special preparation of the patient is required. OMNISCAN should be drawn into the syringe immediately before use. For the intravenous bolus injection in cardiac MRI, the use of a suitable injector is recommended at a rate of up to 8 mL/sec.
For intravenous use. For both adults and children, the required dose should be administered as a single intravenous injection. For cardiac MRI, two injections for stress and rest perfusion examination are required. To ensure complete injection of the contrast medium, the intravenous line may be flushed with sodium chloride injection 0.9%.
Use the lowest effective dose. Calculate the dose based on the patient's body weight, and do not exceed the recommended dose per kilogram of body weight.
CNS: Dosage for adults and children: The recommended dosage is 0.1 mmol/kg body weight (equivalent to 0.2 mL/kg BW) up to 100 kg. Above 100 kg body weight 20 mL is usually sufficient to provide diagnostically adequate contrast.
Adults only: When brain metastases are suspected, a dosage of 0.3 mmol/kg BW (equiv. to 0.6 mL/kg BW) can be administered up to 100 kg. Above 100 kg BW a total of 60 mL is usually sufficient. The dose of 0.3 mmol/kg BW can be administered as a bolus intravenous injection. In patients with equivocal scans after administration of the 0.1 mmol/kg BW injection, a second bolus injection of 0.2 mmol/kg BW (equiv. to 0.4 mL/kg BW) may be of additional diagnostic value when administered within 20 minutes of the first injection.
Whole body: Dosage for adults: The recommended dosage is usually 0.1 mmol/kg BW (equiv. to 0.2 mL/kg BW) or occasionally 0.3 mmol/kg BW (equiv to 0.6 mL/kg BW) up to 100 kg. Above 100 kg BW 20 mL resp. 60 mL is usually sufficient to provide diagnostically adequate contrast.
Dosage for children from 6 months of age: The recommended dosage is 0.1 mmol/kg BW (equiv. to 0.2 mL/kg BW).
CNS and whole body only: Contrast-enhanced MRI should start shortly after administration of the contrast medium, depending on the pulse sequences used and the protocol for the examination. Optimal enhancement is observed within the first minutes after injection (time depending on type of lesion/tissue). Enhancement is generally lasting up to 45 minutes after contrast medium injection. T1-weighted scanning sequences are particularly suitable for contrast-enhanced examinations with OMNISCAN. In the investigated range of field strengths, from 0.15 Tesla up to 1.5 Tesla, the relative image contrast was found to be independent of the applied field strength.
Angiography: Dosage for adults: The recommended dosage is 0.1 mmol/kg b.w. (equiv. to 0.2 mL/kg b.w.). In cases of stenosis of abdominal and iliac arteries, a higher dosage of up to 0.3 mmol/kg b.w. (equiv. to 0.6 mL/kg b.w.) has been shown to provide additional diagnostic information.
Imaging should be performed during the first pass of the contrast agent, during and immediately after injection, depending on the MR equipment used, to obtain contrast effect.
Mammography: Dosage for adults: The recommended dosage is 0.1-0.2 mmol/kg b.w. (equivalent to 0.2-0.4 mL/kg b.w.). Above 100 kg b.w. 20-40 mL is usually sufficient to provide diagnostically adequate contrast.
Coronary Artery Disease (CAD): Dosage for adults: The recommended dosage for evaluation of cardiac perfusion is 0.15 mmol/kg b.w. (equiv. to 0.3 mL/kg b.w.) given as two separate doses of 0.075 mmol/kg b.w. (equiv. to 0.15 mL/kg b.w.) administered within an interval of ≥10 minutes; one at pharmacological stress followed by one at rest.
An adequate pharmacological stress agent should be administered via separate intravenous line. For the evaluation of late enhancement only, a total dose of 0.15 mmol/kg b.w. is recommended. The CAD indication has not been studied in children.
If this medicinal product is intended to be used with an automatic application system, its suitability for the intended use has to be demonstrated by the manufacturer of the medical device.
Instructions for use of the medical device must be followed absolutely.