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Increased bleeding time has been seen when Omacor is given in conjunction with acetylsalicylic acid and warfarin, but without haemorrhagic complications (see PRECAUTIONS).
Acetylsalicylic acid: Patients should be informed about potential increased bleeding time.
Warfarin and coumarin: The prothrombin time/international normalised ratio (PT/INR) must be monitored during combination treatment with Omacor among patients receiving blood-thinning therapy, and when treatment with Omacor is discontinued.
Statins: Omacor 4 g has been administered with simvastatin 80 mg under fasting conditions to 24 healthy volunteers in a two 14-days period drug-drug interaction study. Results of this study demonstrated that at steady state, the co-administration of Omacor capsules with simvastatin did not appear to affect the pharmacokinetics of simvastatin tablets.
The combination appeared to be well tolerated.
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