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Antipsychotic.
Pharmacology: Pharmacokinetics: Olanzapine is well absorbed from the gastrointestinal tract after oral. Olanzapine is about 93% bound to plasma proteins. It is extensively metabolized in the liver, primarily by direct glucuronidation and by oxidation mediated through the cytochrome P450 isoenzymes CYP1A2 and to lesser extent, CYP2D6. The 2 major metabolites 10-N-glucoronide and 4A-N-desmetyhlolanzapine appear to be inactive. About 57% of a dose is excreted in the urine, mainly as metabolites, and about 30% appears in the faeces. The mean plasma elimination half-life has been variously reported to be about 30 to 38 hours; half-lives tend to be longer in female than in male patients. Olanzapine distributed into breast milk.
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