Nutriplete Overdosage

Signs and Symptoms of Overdose: Vitamin A: Hypervitaminosis A, condition that occurs when a person has too much vitamin A in the body, taking more than 25,000 IU weekly. Early sign include fatigue, lack of energy, blurred or double vision, dizziness, headache, insomnia, irritability, depression, loss of appetite, abdominal pain, nausea and vomiting, mild fever and excessive sweating.
Vitamin C: Prolonged intake of Vitamin C more than 2 g per day may lead to nausea, abdominal cramps, diarrhea and nose bleed. High dose of vitamin C may also lead to GI obstruction, esophagitis and elevated serum glucose level. In patients with kidney disease, excessive vitamin C may contribute to kidney stone. In patients with hemochromatosis, a metabolic disease that cause excess iron accumulation, high vitamin C intake may also boost iron absorption.
Vitamin E: Doses of vitamin E greater than 1,000 mg (equivalent to 1,490 IU) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It may increase the risk of thrombosis in some patients, such as those taking estrogen.
Vitamin K1: There is no clinical syndrome attributed to hypervitaminosis of phytomenadione, adverse effects have been reported after overdose in neonates and infants. These includes jaundice, hyperbilirubinemia, increase in liver enzyme values, abdominal pain, constipation, soft stools, malaise, agitation and skin eruptions. Most adverse events were not considered to be serious, and resolved without any treatment.
Copper as cupric oxide: Cirrhosis and acute liver failure have been attributed to chronic excessive copper supplement ingestion. Supplementation with 10 mg daily of copper (around the safe upper limit) for 2 months has been reported to be associated with transient mild increase in serum aminotransferase values. Excessive level of copper accumulation in various parts of the body can lead to Wilson's disease. Symptoms may vary depending on the parts of the body affected such as fatigue, lack of appetite or abdominal pain, jaundice, golden-brown eye discoloration (Kayser-Fleischer rings), fluid buildup in the legs or abdomen, speech problem, swallowing or physical coordination, uncontrolled movements or muscle stiffness.
Manganese as sulfate monohydrate: Excessive manganese levels can lead to manganism that cause psychiatric, motor disturbances and neurologic symptoms consist of reduced response speed, irritability, mood changes, and compulsive behaviors.
Selenium as sodium selenite: Chronic selenium intoxication can result to selenosis, symptoms include fatigue, hair and nail damage or loss, lethargy, dizziness, motor weakness and burning or prickling in the extremities. There is some evidence for chronic impacts at lower doses including heart disease.
Zinc as zinc oxide: Greater than 200 mg daily may cause acute zinc toxicity including GI pain/cramps, nausea, vomiting and diarrhea, loss of appetite, headache, lack of energy, muscle pains and fever. Prolonged zinc supplementation may cause impairment of copper and iron status and anemia at doses greater than 50 mg/day, immune deficiency, reduced blood high-density lipoprotein (HDL) levels, and gastric erosion at doses greater than 150 mg daily. Long-term (average 6.3 years) ingestion of supplemental zinc (80 mg/day) has also been linked to a significant increase in hospitalization for urinary tract infections and kidney stones.
What to do when the patient has taken more than the recommended dosage: If the patient has taken more than the recommended dosage, consult a physician or contact a Poison Control Center right away.