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Impaired Respiration: Nubain 10 mg causes some respiratory depression approximately equivalent to morphine 10 mg. However, in contrast to morphine, respiratory depression is not appreciably increased with higher doses of Nubain. Respiratory depression induced by Nubain can be reversed by naloxone HCl when indicated. It should be administered with caution at low doses to patients with impaired respiration (eg, from other medication, uremia, bronchial asthma, severe infection, cyanosis or respiratory obstruction).
Impaired Renal or Hepatic Function: Because Nubain is metabolized in the liver and excreted by the kidneys, patients with renal or liver dysfunction may over-react to customary doses. Therefore, in these individuals, Nubain should be used with caution and administered in reduced amounts. However, liver and renal function tests on patients who have received Nubain in single and chronic dosages do not reveal any changes attributable to its administration.
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