Nexonav/Nexonav IV Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per Nexonav EC tab Esomeprazole Mg trihydrate. Per Nexonav IV inj Esomeprazole Na

Indications/Uses

Nexonav PUD & other conditions where inhibition of gastric acid secretion may be beneficial including aspiration syndrome, healing of erosive esophagitis, dyspepsia, GERD & Zollinger-Ellison syndrome. Nexonav IV Short-term treatment (up to 10 days) of GERD patients w/ a history of erosive esophagitis as an alternative to oral therapy in patients when therapy w/ esomeprazole EC tab is not possible or appropriate. Treatment of PUD & NSAID-associated ulceration in GERD & Zollinger-Ellison syndrome.

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Dosage/Direction for Use

Nexonav EC tab Adult 1-2 EC tab once daily. Dyspepsia 10 or 20 mg daily for 2-4 wk. GERD 20-40 mg once daily for 4-12 wk or max daily dose of 40 mg for 4-12 wk. Erosive reflux esophagitis 40 mg once daily for 4 wk. PUD 20 mg once daily or 40 mg daily in severe cases, may be continued for 4 wk (for duodenal ulcer) & 8 wk (for gastric ulcer). Maintenance: 10-20 mg once daily. Zollinger-Ellison syndrome Initially 40 mg bid, may be increased to 80-160 mg daily in divided doses or bid. NSAID-associated ulceration 20 mg daily. Nexonav IV inj GERD w/ history of erosive esophagitis Adult 20 or 40 mg once daily by IV inj (not <3 min) or infusion (10-30 min) once daily.

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Overdosage

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Administration

Should be taken on an empty stomach: Nexonav Take at least 1 hr before meals. Swallow immediately, do not chew. Do not store mixt for future use.

Contraindications

Nexonav Hypersensitivity. Nexonav IV Hypersensitivity to esomeprazole Na or to substituted benzimidazoles.

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Special Precautions

Nexonav May interfere w/ antiretroviral drugs & drugs affected by gastric pH changes. Not recommended in pregnancy. Nexonav IV Pregnancy & lactation. Childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Nexonav Diarrhea, nausea, vomiting, headache, rash & dizziness. Nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps & water retention. Nexonav IV Headache, abdominal pain, constipation, diarrhea, flatulence, nausea, vomiting & inj site reaction.

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Drug Interactions

Nexonav Decreased elimination of diazepam. Reduced absorption & blood conc of ketoconazole. Increased absorption & blood conc of digoxin. Increased saquinavir blood levels & reduced nelfinavir & atazanavir blood levels. Nexonav IV Ketoconazole, itraconazole, diazepam, phenytoin, warfarin, cisapride, clarithromycin, atazanavir, nelfinavir, voriconazole, saquinavir.

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Caution For Usage

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Storage

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Description

View Nexonav/Nexonav IV description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Regulatory Classification

Presentation/Packing

Form

Nexonav EC tab 40 mg

Packing/Price

30's

Form

Nexonav IV powd for inj 40 mg

Packing/Price

(+ 10-mL diluent) 1's

Nexonav/Nexonav IV

esomeprazole

Manufacturer:

D & G Pharma

Distributor:

D & G Pharma