Pyridoxine Hydrochloride (Vitamin B6): long term administration of large doses is associated to the development of severe peripheral neuropathies, sensory neuropathy, paresthesia, somnolence, low serum folic acid levels.
Cyanocobalamin (Vitamin B12): may aggravate Leber's disease or tobacco amblyopia, allergic hypersensitivity, gasping syndrome in premature infants.
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