Neozep Z+ Forte/Neozep Z+ Non-Drowsy Drug Interactions

Do not use this product together with sympathomimetic agents (e.g., epinephrine) and general anesthetics (e.g., halothane) because of the possibility for increased toxicity.
Concurrent administration with medicines for depression such as monoamine oxidase (MAO) inhibitors (e.g., selegiline, moclobemide) and tricyclic antidepressants (e.g., amitriptyline, imipramine) may result in hypertensive crisis (sudden, severe increase in blood pressure that can lead to stroke).
Taking an alpha-adrenergic blocking agent (e.g., phenothiazine drugs, phentolamine) before the administration of this product may decrease the effect of phenylephrine. Concomitant use with beta-adrenergic blocking agents (e.g., propranolol) and methyldopa may cause an increase in blood pressure.
Paracetamol, when used together with warfarin (a blood-thinning medicine), may cause an increase in the International Normalized Ratio (INR), which may serve as a sign of increased risk for bleeding. Paracetamol increases the anticoagulation effect of warfarin.
Medicines which stimulate the enzymes responsible for the metabolic activation of paracetamol such as medicines for convulsion (e.g., phenobarbital, phenytoin) may increase susceptibility to the harmful effects to the liver.
The absorption of paracetamol may be accelerated by metoclopramide or domperidone and reduced by cholestyramine.
Zinc decreases the absorption of certain antibiotics such as quinolones (e.g., ciprofloxacin, levofloxacin, ofloxacin) and tetracyclines (e.g., doxycycline, tetracycline). Zinc salts should be given 2 hours after or 6 hours before antibiotics.
Concomitant intake of a bisphosphonate (e.g., alendronate, etidronate, risedronate) and zinc may decrease the absorption of both the bisphosphonate and zinc.
Zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Additive effects are possible with concurrent administration of zinc and cholesterol medicines; use with caution.
Tell the doctor about other medicines the patient is taking (i.e., other medicines for cough, cold, allergy, pain, or fever, especially other paracetamol-containing products).
Neozep Z+ Forte: Medicines that cause sedation such as anxiolytics (e.g., alprazolam, diazepam) and hypnotics (e.g., zolpidem) may potentiate drowsiness.