Hematologic: Anemia, bleeding, leukocytopenia, and thrombopenia.
Hypersensitivity: Fever, chills, and urticaria have been reported occasionally. Anaphylaxis may occur.
Hepatic: Hepatic impairment has been reported occasionally.
Renal: Occasionally, proteinuria has been reported.
Gastrointestinal: Acute nausea and vomiting occurs frequently and may be severe. Mucositis (stomatitis and esophagitis) may occur 5 to 10 days after administration. Anorexia and diarrhea have been occasionally reported.
Cutaneous: Reversible complete alopecia occurs in most cases. Hyperpigmentation of nail beds and dermal creases have been reported in a few cases.
CNS: Fatigue and headache occurs frequently.
Urinary system: Cystic stimulation symptoms (oliguria, urodynia, urocystitis, hematuria) by vesicoclysis therapy.
Respiratory system: Pneumothorax during treatment which metastasize to the lungs.
Other: Febricity, occasionally facial edema may occur.
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