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Interactions of filgrastim with other cytokines, including hematopoietic growth factors, have been observed in animal studies. The safety, efficacy and possible interactions of filgrastim used in combination with other cytokines have not been characterized in clinical trials.
Drug interactions between filgrastim and other drugs have not been fully evaluated. Drugs which may potentiate the release of neutrophils, such as lithium, should be used with caution.
Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone imaging changes. This should be considered when interpreting bone-imaging results.
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