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Abrupt withdrawal of the drug should be avoided and it should not be used by patients who have bronchospastic disease unless the patients do not respond to, or cannot tolerate other anti-hypertensive drug. In such cases, the lowest possible dose should be used and a β2-agonist should be administered concomitantly.
METOPROLOL tartrate may prolong hypoglycemic effect of insulin and should therefore be used with caution in diabetic patients especially those with labile diabetes. METOPROLOL tartrate therapy must be reported to the anaesthetist prior to general anaesthesia. Administration during the first trimester of pregnancy is not recommended.
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