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Drugs that affect testosterone: Barbiturates and other enzyme inducers: Interactions can occur with drugs that induce microsomal enzymes which can result in increased clearance of testosterone.
Effects of androgens on other drugs: Oxyphenbutazone: Increased oxyphenbutazone serum levels have been reported.
Oral anticoagulants: Testosterone and its derivatives have been reported to increase the activity of coumarin derived oral anticoagulants, possibly requiring dose adjustment. Independent of this finding, the risk of bleeding from using intramuscular injections in patients with acquired or inherited bleeding disorders always has to be taken into account as a general rule.
Hypoglycaemics: Androgens may enhance the blood sugar reducing effects of insulin. Therefore, the dosage of hypoglycaemic agents may need to be lowered.
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