Mytoxid Drug Interactions

Concomitant of combination with other malignant antitumor agent or irradiation, bone marrow suppression could be occur, therefore state of patients should be monitored regularly and be cautioned with the reduction of dose.
Acute shortness of breath and severe bronchospasm have been reported following the administration of vinca alkaloids (i.e. vincristine sulfate, vinblastine sulfate and vindesine sulfate) in patients who had previously or simultaneously received mitomycin.
In case of combination with phenytoin, hepatic metabolism of cytotoxic substance may increase concomitant to use of busulfan, ifosfamide, etoposide and teniposide.
Combination with yellow fever vaccine could cause generalized or fetal disease, therefore combination with the drug should be avoided.
In case of combination with doxorubicin, cardiotoxicity may increase because of formation of free radical.
Possibility of lung damage has been reported due to uratic nitrogen, and doxorubicin.
Barbiturate may increase the effect of the drug.