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Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with antithrombotic activity such as garlic and ginkgo.
Vitamin E may enhance the side effects of some drugs (i.e., amiodarone, ciclosporin, and zidovudine).
Vitamin E may reduce the requirement for digoxin and/or insulin. Monitoring is recommended.
Orlistat may result in decreased vitamin E absorption. Therefore, orlistat should be taken two hours before or two hours after vitamin E administration. Other drugs that may interfere with absorption/utilization of vitamin E include colestyramine, colestipol, isoniazid, mineral oil, neomycin, and sucralfate.
Anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine) and/or oral contraceptives may lower plasma levels of Vitamin E.
Dietary fiber supplementation may decrease the antioxidative effect of a supplement containing vitamin E.
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