Myra 300-E

Each capsule contains: dL-Apha Tocopheryl Acetate (Vitamin E) 300 I.U.
Antioxidants function as scavengers to detoxify free radicals. Free radicals are highly reactive and unstable chemicals formed in the body during normal physiological and biochemical processes such as respiration, metabolism and immune system response.
This product contains dL-Alpha Tocopherol (Vitamin E), a fat-soluble antioxidant which acts as the first defense against free radicals in the lipid (fat) phase of cells.
Vitamin E promotes cell and tissue renewal of the skin, heart, lungs, muscles, and liver. It modulates the synthesis of prostaglandins important for the body's immune response. Vitamin E is also involved in the metabolism of nucleic acid and the functioning of the mitochondria which is the main site of energy production in cells.

For the prevention and treatment of Vitamin E deficiency.

Orally, one softgel capsule once a day.
Or as prescribed by a physician.
Missed Dose: If the patient misses a dose, just take the next dose and the subsequent doses at the usual recommended schedule, i.e., once a day.
Do not double the dose.

There are no available data on acute overdosage with vitamin E.
However, large doses (>1,490 I.U. daily for prolonged period) have occasionally been associated with side effects (see Adverse Reactions).
If the patient has taken more than the recommended dosage, consult a doctor.

If the patient is allergic to any component in the product.

High doses of vitamin E [i.e., doses greater than 100 mg (equivalent to 149 I.U.) daily of d-Alpha Tocopherol] should be used with caution in patients on warfarin. Monitoring of international normalized ratio (INR) and adjusting of warfarin dose (if indicated) are recommended. Likewise, those with vitamin K deficiencies, such as patients with liver failure, should be cautious in taking high doses of vitamin E.
Vitamin E should be used with extreme caution in those with any lesions that have a tendency to bleed (e.g. bleeding peptic ulcers), those with a history of hemorrhagic stroke, and those with inherited bleeding disorders (e.g., hemophilia).
High dose of vitamin E supplementation should be stopped about one month before a surgical procedure and may be resumed following recovery from the procedure, or as directed by a doctor.
Do not use more than the recommended dose.
Consult a doctor: If any undesirable effect occurs.
If the patient is pregnant or thinks may be, or is planning to become pregnant, or is breastfeeding. The effects of high doses of vitamin E during pregnancy and breastfeeding are not known.

Vitamin E is relatively nontoxic and is usually well-tolerated. Most adults can tolerate 100 to 800 mg (equivalent to 149 to 1,192 I.U. of d-Alpha Tocopherol) daily without undesirable effects. However, the vitamin (e.g., at dosages exceeding 300 I.U. daily) has rarely caused nausea, diarrhea, abdominal pain/intestinal cramps, fatigue/weakness, headache, dizziness, blurred vision, emotional disturbances, and rash. Myopathy (muscle disorder), hypertension, thrombophlebitis (vein inflammation related to blood clot), gonadal dysfunction, breast soreness/gynecomastia, creatinuria (increased concentration of creatine in the urine), increased serum creatine kinase, serum cholesterol, and triglycerides; increased urinary estrogens and androgens; and thyroid problems have also been noted. These effects generally disappeared after discontinuing the vitamin.
Doses of vitamin E greater than 1,000 mg (equivalent to 1,490 I.U. of d-Alpha Tocopherol) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens.

Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with antithrombotic activity such as garlic and ginkgo.
Vitamin E may enhance the side effects of some drugs (i.e., amiodarone, ciclosporin, and zidovudine).
Vitamin E may reduce the requirement for digoxin and/or insulin. Monitoring is recommended.
Orlistat may result in decreased vitamin E absorption. Therefore, orlistat should be taken two hours before or two hours after vitamin E administration. Other drugs that may interfere with absorption/utilization of vitamin E include colestyramine, colestipol, isoniazid, mineral oil, neomycin, and sucralfate.
Anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine) and/or oral contraceptives may lower plasma levels of Vitamin E.
Dietary fiber supplementation may decrease the antioxidative effect of a supplement containing vitamin E.

Store at temperatures not exceeding 30°C. Protect from light.

Vitamins A, D & E

A11HA03 - tocopherol (vit E) ; Belongs to the class of other plain vitamin preparations. Used as dietary supplements.

Non-Rx