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Clinical studies demonstrated that the administration of up to 500 mg single doses of etoricoxib and multiple doses up to 150 mg/day for 21 days did not result to significant toxicity. Cases of acute etoricoxib overdosage have been reported; however, adverse experiences were not reported in the majority of these cases. The most commonly observed adverse experiences were consistent with the safety profile for etoricoxib (e.g., gastrointestinal and cardiorenal events).
Usual supportive measures (e.g., removal of unabsorbed material from the GI tract, clinical monitoring) must be performed during overdose. Supportive therapy should be instituted, if required.
Etoricoxib is not dialyzable by hemodialysis; it is not known whether etoricoxib is dialyzable by peritoneal dialysis.
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