Concurrent and/or sequential systemic or topical use of other potentially neurotoxic and/or nephrotoxic drugs should be avoided. The concurrent use of gentamicin with potent diuretics should be avoided, since certain diuretics themselves may cause ototoxicity. A reduction in gentamicin serum half life has been reported in patients with severe renal impairment receiving carbenicillin concomitantly with Gentamicin. Appropriate therapy is indicated if treatment with Gentamicin results in severe growth of nonsusceptible microorganisms.