Moxgen-457 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Co-amoxiclav (amoxicillin & clavulanic acid). Per 5 mL Amoxicillin 400 mg, clavulanic acid 57 mg

Indications/Uses

Short term treatment of common bacterial infections eg, URTI, including ENT (eg, tonsillitis, sinusitis, otitis media), lower resp tract (eg, acute & chronic bronchitis, lobar & bronchopneumonia), GUT (eg, cystitis, urethritis, pyelonephritis, female genital infections), skin & soft tissue, bone & joint (eg, osteomyelitis), & other (eg, septic abortion, puerperal & intra-abdominal sepsis, septicaemia, peritonitis & post-surgical infections) infections. Prophylaxis against infections associated w/ major surgical procedures eg, GI, pelvic, head & neck, cardiac, renal, joint replacement & biliary tract.

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Dosage/Direction for Use

Childn >6 yr (18-40 kg) 5 mL tid, may be increased up to 50 mg/kg daily in divided doses every 8 hr in severe infections. Childn <12 mth 25 mg/kg daily eg, 7.5-kg child would require 2 mL tid.

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Overdosage

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Administration

May be taken with or without food: Best taken at start of meal for optimised absorption.

Contraindications

History of allergic reaction to β-lactams (eg, penicillins or cephalosporins). Patients w/ previous history of co-amoxiclav associated jaundice/hepatic dysfunction.

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Warnings

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Special Precautions

Not to be used w/ drugs that delay peristalsis (eg, opiates & diphenoxylate w/ atropine), which may prolong &/or worsen condition. Provide fluids, electrolytes & protein replacement therapy when indicated. Patients w/ evidence of hepatic dysfunction. Contains aspartame; patients w/ phenylketonuria. Avoid use in pregnancy, especially during 1st trimester, unless considered essential. Lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Gastritis, stomatitis, glossitis, black "hair" tongue, indigestions, nausea, vomiting, diarrhea, enterocolitis, pseudomembranous colitis & candidiasis; skin rashes & urticaria; transient hepatitis & cholestatic jaundice; anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia & agranulocytosis.

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Drug Interactions

May precipitate disulfiram-like (antabuse) reaction w/ alcohol. Amoxicillin: Transient decrease in plasma conc of total conjugated estriol & estradiol to pregnant women. Decreased renal tubular secretion that may result in increased & prolonged blood levels w/ probenecid. May increase incidence of rashes in patients receiving allopurinol.

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Caution For Usage

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Storage

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Description

View Moxgen-457 description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Penicillins

ATC Classification

J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Moxgen-457 powd for susp 457 mg/5 mL

Packing/Price

(raspberry flavour) 30 mL x 1's; (raspberry flavour) 70 mL x 1's

Moxgen-457

amoxicillin + clavulanic acid

Manufacturer:

Giyaan Pharma

Distributor:

Quad-Gen

Marketer:

Ambica